References
Episode 6 Women's Health
[6:30] Healthy Menstrual Cycle
A healthy menstrual cycle begins with FSH stimulating a rise in estrogen, followed by an LH surge that triggers ovulation; progesterone then increases to prepare the uterine lining for pregnancy, and if fertilization does not occur, estrogen and progesterone levels fall, leading to the shedding of the uterine lining.
Reference: Reproductive aging in biological females[7:30] Perimenopause
Perimenopause and menopause are biologically programmed phases of life written into women’s DNA — a natural transition every woman will experience.
Reference: Menopause-related changes to maxillary trabecular bone micro-architecture[7:45] Perimenopause Part 2
Perimenopause typically begins in a woman’s 40s, as estrogen and progesterone levels decline while FSH rises and remains elevated, contributing to many of the symptoms associated with the transition.
Reference: Reconsidering Hormone Replacement Therapy[8:30] Hormonal Changes
Many factors contribute to timing of hormonal changes — diet, lifestyle, genetics, medications
Reference: Reconsidering Hormone Replacement Therapy[8:45] Hysterectomy
A hysterectomy that removes the organs involved in hormone production and regulation can abruptly trigger menopause by disrupting the body’s natural hormonal cycle.
Reference: Reproductive aging in biological females[9:10] Duration of Perimenopause
Duration of perimenopause is typically 3–4 years but can last as long as 10 years
Reference: Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause[9:30] Start of Menopause
Menopause is official after 12 months without menstrual cycle — symptoms include vaginal dryness, hot flashes, night sweats, and bone loss.
Reference: The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients[10:20] Osteoblasts & Osteoclasts
Osteoblasts and osteoclasts constantly remodel bones — hormone fluctuations alter how effectively the body manages bone health.
Reference: Research progress on FSH-FSHR signaling in the pathogenesis of non-reproductive diseases[10:40] Symptoms of Menopause
Other symptoms of menopause include mood changes, changes in libido, and weight gain — hormone fluctuations affect fat storage.
Reference: Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause[11:30] Pregnancy & Perimenopause
Pregnancy during perimenopause is still possible but more challenging.
Reference: Reconsidering Hormone Replacement Therapy: Current Insights on Utilisation in Premenopausal and Menopausal Women[12:30] HRT
Hormone replacement therapy artificially increases estrogen and progesterone.
Reference: Reconsidering Hormone Replacement Therapy[13:00] HRT Risks
HRT has known risks — breast cancer, ovarian cancer, blood clots, strokes.
Reference: The risk of ovarian cancer in hormone replacement therapy users[14:00] HRT & Biology
HRT pushes back against biology — may smooth symptoms but may put women in a higher risk category.
Reference: Reconsidering Hormone Replacement Therapy[14:30] Exercise & Metabolism
Exercise boosts metabolism, supports cardiovascular health, lowers cortisol — helps with mood and sleep.
Reference: The Effects of Menstrual Cycle Phase on Elite Athlete Performance[15:20] Deep Breathing
Deep breathing and meditation for menopause symptom support.
Reference: Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause[15:50] Processed Foods
Processed foods and diets high in refined carbs are not helpful for hormonal support — diets higher in fiber, lower in sugar are preferable.
Reference: Reproductive aging in biological females[16:30] Reducing Screen Time
Reducing screen time before bed and keeping the bedroom cool help with sleep quality.
Reference: Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause[17:00] Phytoestrogen Compounds
Soy isoflavones, red clover, flax lignans have phytoestrogen compounds — similar to HRT in some ways; caution about boosting estrogen.
Reference: Dietary Vitamin E Isoforms Intake[17:50] Black Cohosh
Black cohosh is a SERM — binds serotonin receptors that regulate body temperature; helps with hot flashes and mood without elevating estrogen.
Reference: Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health[18:30] Estro-G
Estro-G is a blend of three plants that work like black cohosh (SERM) — helps hot flashes, stimulates estrogen-type responses without raising estrogen, elevates ATP and energy.
Reference: Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health[20:30] MCHA
Bone supplements should feature MCHA (microcrystalline hydroxyapatite) form of calcium containing phosphorous — add fat-soluble vitamins D and K.
Reference: The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients[21:20] Omega-3 & Creatine
Omega-3s and Creatine can be supportive for women going through hormone fluctuations.
Reference: Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid[21:30] Aloe Vera
Aloe vera gel or jojoba oil can support vaginal dryness symptoms.
Reference: Reconsidering Hormone Replacement Therapy[22:30] DIM
DIM is derived from cruciferous vegetables and helps smooth out estrogen hormone fluctuations.
Reference: Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane[22:50] Berberine
Berberine helps smooth out blood sugar balance and supports overall metabolism and weight management.
Reference: Pharmacological properties and therapeutic potential of berberine[23:15] Myo-Inositol
Myo-Inositol helps with insulin sensitivity and PCOS support.
Reference: Study on the Effect of Berberine, Myoinositol, and Metformin in Women with Polycystic Ovary Syndrome[23:30] Cranberry
Cranberry has been a traditional tool for urinary tract support — UTIs are extremely common among women.
Reference: Cranberry-derived bioactives for the prevention and treatment of urinary tract infections[24:00] D-Mannose
D-Mannose acts fast where cranberry is longer-lasting — similar anti-adhesion mechanism, bacteria cannot adhere and grow.
Reference: Considerations on D-mannose Mechanism of Action and Consequent Classification of Marketed Healthcare Products[24:49] Phytoestrogens
Soy isoflavones and red clover have phytoestrogens.
Reference: Dietary Vitamin E Isoforms Intake[25:00] Maca
Maca is an adaptogen that can help balance adrenals, thyroid, sex hormones, and lower cortisol.
Reference: The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance[25:30] MCHA Part 2
Calcium microcrystalline hydroxyapatite (MCHA) is a ‘whole food’ form of calcium containing phosphorous and protein-like molecules.
Reference: The Role of Follicle-Stimulating Hormone in Bone Loss During Menopause Transition[25:50] Probiotics
Probiotics support gut-brain axis health and vagal nerve health — helpful during menopause and perimenopause.
Reference: The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis[26:00] Saffron
Saffron can support emotional health and mood — can be combined with probiotics.
Reference: From Mood to Memory[27:00] Anxiety in Women
Women are twice as likely to suffer from anxiety and mood health challenges — hormone fluctuation plays a role.
Reference: Progesterone and Its Metabolites Play a Beneficial Role in Affect Regulation in the Female Brain[28:15] Ashwagandha
Ashwagandha can help support the body’s stress response.
Reference: Effects of Ashwagandha Supplements on Cortisol, Stress, and Anxiety Levels in Adults[28:20] L-Theanine
L-Theanine helps increase alpha-waves in the brain — relaxation without drowsiness.
Reference: l-Theanine as a Functional Food Additive[28:30] Magnesium
Magnesium is one of the most important minerals — acts on NMDA receptors in the brain that can go unchecked and raise stress levels.
Reference: The Effects of Magnesium Supplementation on Subjective Anxiety and Stress[29:12] GABA
GABA can help ‘turn off the noise’ — helps us focus and relax.
Reference: Magnesium and the BrainEpisode 5 Ask Doctor Jason FULL Episode 5 – Gut Health + Probiotics
[2:10] Electrolytes
There is no hard and fast rule when it comes to “too much” electrolytes or “upper limit” but they’re designed to give you electrical stimulating minerals.
Reference: Fluid and Electrolyte Balance[4:05] Erectile Dsyfunction
ED can be linked to high blood pressure.
Reference: Can High Blood Pressure Cause Erection Problems?[4:06] Beet Root
Episode 5: Erectile Dsyfunction
Reference: Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes[7:15] Eli Metchnikoff
Eli Metchnikoff and the bulgarian peasants – the beginning of probiotic research.
Reference: Bulgarian yogurt: An old tradition, alive and well[8:25] Gut Health
Gut health is not just about digestion and immunity anymore – gut microbiome operates almost like an organ.
Reference: Role of the normal gut microbiota[10:15] Fiber
Fiber is key part of diet for supporting a healthy microbiome. slows absorption of sugar, and feeds living organisms.
Reference: Gut microbiota modulation by dietary fiber on human health[11:00] Food Engineering
Universities now teach “food engineering” what used to be called “farming”.
Reference: Agriculture and Food Careers[11:50] Gut Brain Axis
Gut brain axis and the serotonin connection – most serotonin produced in the gut.
Reference: Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation[13:00] Vagus Nerve
The vagus nerve and the surprising connection between gut and brain where most of the signals come from the gut to the brain.
Reference: The vagus nerve’s mysterious role in mental health untangled[14:00] Gut & Mental Health
Taking care of gut health can impact emotional and mental health.
Reference: A randomised controlled trial of dietary improvement for adults with major depression[14:40] Yogurt's Bacteria
Many store-bought yogurts are not very high in living bacteria and instead have sugars, colors, etc.
Reference: Rethinking Yogurt’s Probiotic Value[16:00] Dysbiosis
Modern foods and chemicals including antibiotics and lead to “dysbiosis” or dysregulated gut microbiome.
Reference: Dysbiosis and the modern lifestyle[16:20] Smoking
Smoking is a factor that contributes to poor outcomes during menopause.
Reference: Reconsidering Hormone Replacement Therapy[16:30] Probiotics & Antibiotics
Probiotics have value right after or during antibiotics
Reference: Probiotics for the prevention of antibiotic-associated diarrhoea[17:15] Probiotics & Antibiotics part 2
Timing of probioitc supplements around antibiotics.
Reference: Can you take probiotics with antibiotics?[17:30] Probiotic Delivery
Delivery systems with probiotics are important.
Reference: Encapsulation of probiotics: past, present and future[18:00] Living Bacteria
Probiotics are living bacteria – need to deliver them alive.
Reference: Survival of Probiotic Lactobacilli in Acidic Environments Is Enhanced in the Presence of Metabolizable Sugars[18:30] Postbiotics
Probiotic organisms produce a lot of products in their lifecycle nowadays called “postbiotics”.
Reference: The International Scientific Association of Probiotics and Prebiotics[20:00] Butyrates
Probiotics create Butyrates, bacteriocins, vitamins, etc.
Reference: Bioactive molecules of probiotic bacteria and their mechanism of action[20:25] Probiotic's Environment
Probioitics help create a challenging environment for harmful bacteria.
Reference: The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome[21:30] Shipping Probiotics
Most probioitics are not shipped cold to the store.
Reference: Evaluation of Probiotic Survivability in Yogurt Exposed To Cold Chain Interruption[22:00] Shelf Stable Probiotics
“Shelf-stable” probiotics have become one of the fastest growing segments in the category.
Reference: Heat-Stable Probiotics Market to Reach USD 12.7 Billion by 2036...[22:30] "Shelf-Stable" Probiotics part 2
Most of the probioitcs currently sold in the fridge are relatively shelf stable at room temperature.
Reference: Heat-Stable Probiotics Market to Reach USD 12.7 Billion by 2036...[23:00] Probiotic's Sensitivity
Probiotics are sensitive to extreme heat, and also sensitive to moisture.
Reference: Pilot-scale Production and Viability Analysis of Freeze-Dried Probiotic Bacteria Using Different Protective Agents[23:45] Blister Trays
Blister trays are among the best protection from moisture and keeps every capsule protectedbetter than a twist-cap bottle.
Reference: Pilot-scale Production and Viability Analysis of Freeze-Dried Probiotic Bacteria Using Different Protective Agents[24:20] Symbiotics
“Symbiotics” are not just living bacteria it’s the prebiotic fiber + the postbioitic compounds built during their lifecycle all together.
Reference: The Future of Synbiotics[26:15] Postbiotics
Postbiotics may reduce competition among the healthy bacteria.
Reference: Gut Microbiota-Targeted Diets Modulate Human Immune Status[27:30] Coated Delivery System
The probiotic bacteria in supplements have difficulty surviving through stomach acid and should be coated in a delivery system to help survival into the colon.
Reference: Probiotic survival during a multi‐layered tablet development...[28:30] Enteric Coating
May brands of probiotic use an older technology called “enteric coating” which uses methyl acrylate or pthallate.
Reference: Targeted Release of Probiotics from Enteric Microparticulated Formulations[29:15] Phthalates
Phthalates are being identified as hormone disruptors
Reference: Phthalates and Their Impacts on Human Health[29:30] Daily Probiotics
Probiotics can be taken every day.
Reference: An insight into the functional alterations in the gut microbiome[30:00] Probiotic Colonization
It is difficult for supplemental probiotics to colonize permamently in the gut.
Reference: The Networked Interaction between Probiotics and Intestine in Health and Disease[30:30] Bacteria Disruption
Many types of medications, not just antibiotics, can disrupt bacteria in the human microbiome.
Reference: Drug-mediated disruption of the aging gut microbiota and mucosal immune system[31:25] Choline Bitartrate
Choline bitartrate is a more bioavailable form that is often promoted for liver and brain support. a readily available source of acetyl choline. Can be valuable
Reference: Future Directions in Choline[32:10] Vitamin E
Vitamin E is an essential vitamin with an RDI established by the government. Make sure you get the “D-Alpha tocopherol” which is the natural form.
Reference: itamin E and Metabolic Health[33:10] Mixed Tocopherols
Look for mixed tocopherols with your vitamin E supplement as the superior form over just D-alpha tocopherol alone.
Reference: Chemopreventive Activity of Vitamin E in Breast Cancer[33:45] Liquid Vitamin E
Liquid vitamin E can help support skin healing but should ideally be used when the healing of the skin cells is already underway rather than too early on in the healing process.
Reference: Vitamin E for Scars[34:30] Yohimbe
Yohimbe is a stimulant-like herbal supplement can raise blood pressure and is associated with some negative side effects.
Reference: Multifaced Nature of Yohimbine[35:30] DMG
DMG has been used to support immune health and oxygenation. It is also helpful for athletic performance.
Reference: Structural, Thermal, and Vibrational Properties of N,N-Dimethylglycine[36:40] Progesterone
Progesterone is a hormone-like compound that has been used to support hormone balance but should be used carefully and with care of a health care practitioner.
Reference: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine[37:50] Sea Moss
Sea Moss is a “superfood” supplement that is touted as having essential minerals and vitamins.
Reference: Seaweed as a Safe Nutraceutical Food[38:40] Branched Chain Amino Acids
Branched Chain Amino Acids are helpful for athletic performance and recovery. Can be helpful for athletes but do not taste very good!
Reference: Branched-Chain Amino Acids and Inflammation Management in Endurance Sports[40:15] D-Mannose
D-Mannose is a sugar-like compound that is known for urinary tract support.
Reference: Considerations on D-mannose Mechanism of Action...[41:00] MCT Oil
MCT oil is a “medium chain saturated fats” are readily absorbed into the body for energy and helpful for energy and weightloss.
Reference: Food Intake and Satiety Response after Medium-Chain Triglycerides Ingested as Solid or Liquid[41:30] Coconut Oil
Coconut oil is naturally high in MCT oil.
Reference: Coconut oil and medium-chain fatty acids attenuate...[42:00] Fenugreek
Fenugreek became known for supporting blood sugar and more recently it has been investigated for testosterone support.
Reference: Fenugreek derived diosgenin as an emerging source for diabetic therapy[43:00] Fenugreek part 2
Fenugreek for testosterone support – identifying the correct potency.
Reference: Libifem® (Trigonella foenum-graecum) in conjunction with exercise on muscle strength...[44:30] Testosterone
What is “correct” range for healthy testosterone for men in their 40s?.
Reference: Low Testosterone in Adolescents & Young Adults[46:30] Ashwagandha
Ashwagandha has been studied to help with stress and athletic performance and healthy testosterone.
Reference: The benefits of ashwagandha[46:50] Ashwagandha part 2
Ashwagandha is known as an adaptogen.
Reference: The benefits of ashwagandha[48:45] L-Theanine
L-Theanine helps increase alpha-waves in teh brain — a measure of relaxation. It will not make you sleepy.
Reference: L-Theanine: A Unique Functional Amino Acid[49:15] Saffron
Saffron extract can help to elevate mood. It may be related to serotonin in the body.
Reference: Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults[50:30] Omega-3
High-EPA omega-3 formulas have been studied for supporting mood
Reference: Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid[51:00] Theanine, Ashwagandha, Saffron, and Omega-3
Theanine, ashwagandha, saffron, and omega-3 fatty acids can all be taken together.
Reference: Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative ActionEpisode 4 Ask Doctor Jason FULL Episode 4 – GLP-1 Deep Dive + Nicolletta Payne Interview
[01:01:30] Body Types
Endomorph, ectomorph, and mesomorph are commonly used terms to describe different body types and general physical tendencies.
Reference: Somatotype and body composition of healthy adult men and women and their contribution to civilization diseases risk[5:05] Proteins on the DIASS
Whey protein is the king of protein, the DIASS backs that up.
Reference: Digestible indispensable amino acid score (DIAAS)[5:45] Protein and Lack of Essential Aminos
Plant proteins lack some of the essential aminos required for human health
Reference: Can the digestible indispensable amino acid score methodology decrease protein malnutrition[6:01] Milk & Whey are a Perfect Match for Humans
Milk protein and whey protein are near perfect match for human consumption per the “protein scoring systems” such as DIAAS
Reference: Values for digestible indispensable amino acid scores...[7:00] GLP-1 Targeting Diabetes
GLP-1 drugs started out as drugs tartgeted at Diabetes
Reference: An Update on GLP‐1 Receptor Agonists[7:30] Sugar and the Reward System
Sugar is one of the most addictive substnces on the planet – more addictive than cocaine. hits your pleasure center HARDER than cocaine.
Reference: Intense Sweetness Surpasses Cocaine Reward[8:05] Processed Foods
Food engineers create highly processed foods designed to be addictive. They do this to increase consumption. Modern food processing also contributes to “food noise.”
Reference: From Tobacco to Ultraprocessed Food[8:40] GLP-1 in the Body
GLP-1 naturally occurs in your body.
Reference: How to activate GLP-1 naturally[9:30] GLP-1 Mimics
Modern pharmaceutical versions don’t give you actual GLP-1 they instead give you a mimic.
Reference: Additives in Processed Foods as a Potential Source of Endocrine-Disrupting Chemicals[10:15] Brain Receptors
Different receptors in the brain respond to hormones that regulate hunger. These signals help control appetite and communicate when you’re full.
Reference: Satiety: a gut–brain–relationship[10:50] GLP-1 and Appetite
GLP-1 is not just an appetite suppressant—it also helps you stay full longer.
Reference: Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss[11:35] How GLP-1 Works
Delaying stomach emptying is a key part of how GLP-1 works.
Reference: Effects of GLP-1 on appetite and weight[12:30] GLP-1 and Weight Loss
GLP-1 drugs are effective for weight loss and can also help many people better control blood sugar levels.
Reference: Glucagon-Like Peptide-1 Receptor Agonist Mediated Weight Loss and Diabetes Mellitus Benefits[13:20] GLP-1 and Side Effects
The most common side effects of GLP-1 include nausea, gastrointestinal upset, diarrhea, and stomach pain.
Reference: Adverse Effects of GLP-1 Receptor Agonists[13:40] GLP-1 is Less Supervised
Some people are using GLP-1 medications in a less supervised way, such as receiving them through mail-order services rather than through traditional, in-person medical care.
Reference: Compounded glucagon-like peptide-1 receptor agonists for weight loss[14:45] Ozempic Face
Side effects of GLP-1 can also include muscle loss. In some cases, fat loss may lead to changes in facial appearance—sometimes referred to as “Ozempic face”—such as increased facial hollowing or more noticeable wrinkles.
Reference: Ozempic Face” in Plastic Surgery[15:20] GLP-1 and Thyroid Health
Some researchers have raised concerns about thyroid health in people taking GLP-1 medications.
Reference: Risk of Thyroid Tumors With GLP-1 Receptor Agonists[16:00] GLP-1 and Weight Gain
Many people regain weight after stopping GLP-1 medications.
Reference: Metabolic rebound after GLP-1 receptor agonist discontinuation[18:10] Electrolytes
Electrolytes can be helpful for recovery after exercise.
Reference: Oral Rehydration Beverages for Treating Exercise-Associated Dehydration[18:40] HMB and Sarcopenia
HMB is sometimes used as a supplement to help preserve muscle mass and may help slow sarcopenia.
Reference: The effects of β-hydroxy-β-methylbutyrate or HMB-rich nutritional supplements on sarcopenia patients[19:25] Creatine and Water Retention
Creatine can increase water retention, which may temporarily affect body measurements and make someone trying to lose inches feel like progress is slower.
Reference: Creatine supplementation protocols with or without training interventions on body composition[19:50] Ginger
Ginger can help support inflammatory response and digestive health.
Reference: Pharmacological properties of ginger (Zingiber officinale)[20:14] Digestive Enzymes
Digestive enzymes can also help you break down your food more effectively.
Reference: A Multi-Digestive Enzyme and Herbal Dietary Supplement Reduces Bloating in a Single Use in Healthy Adults[20:45] GLP-1 and Nutrient Intake
People on GLP-1 medications may sometimes have reduced nutrient intake, which can make a multivitamin helpful for supporting overall nutrition.
Reference: Micronutrient and Nutritional Deficiencies Associated With GLP-1 Receptor Agonist Therapy[23:00] L-Carnitine
L-carnitine is an amino acid that helps transport fatty acids into cells to be used as fuel. It has been studied for many years.
Reference: The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation[23:30] Bee Propolis
Bee propolis contains antimicrobial properties and may help support immune health.
Reference: A review on dynamic pharmacological potency and multifaceted biological activities of propolis[24:30] Berberine
Berberine may help support blood sugar and insulin regulation and can be useful for blood sugar management.
Reference: The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders[25:00] Berberines Absorption Rate
Berberine has a very low absorption rate—less than 1% in some studies.
Reference: Bioavailability Study of Berberine and the Enhancing Effects of TPGS on Intestinal Absorption in Rats[26:10] CoQ10
CoQ10 is a powerful antioxidant with substantial research supporting cardiovascular health. It may be especially important for people with significant heart concerns and is often considered by those taking statin medications.
Reference: Coenzyme Q10:[27:20] Methylated B Vitamins #1
Methylated B vitamins are pre-activated forms that the body can use more readily and efficiently.
Reference: Effect of Methylfolate, Pyridoxal-5′-Phosphate, and Methylcobalamin (SolowaysTM) Supplementation...[29:30] Episode 4: Methylated B Vitamins #1
Methylated B vitamins are also often easier on the stomach and may have a milder smell.
Reference: Possible Benefits of Methylated Multivitamins Explained[30:10] Glucosamine Chondroitin
Glucosamine and chondroitin are controversial in the research, with large-scale studies producing conflicting results on their effectiveness.
Reference: Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee[30:30] Hyaluronic Acid
Hyaluronic acid has been studied for joint health.
Reference: Role of oral hyaluronic acid for joint health[30:50] DIM
DIM is derived from cruciferous vegetables and is often used as a supplement to support estrogen metabolism.
Reference: Exploring the impact of 3,3’-diindolylmethane on the urinary estrogen profile of premenopausal women[31:25] Elderberry
Elderberry contains powerful antioxidants and is commonly used to support immune health. It may be more effective when used preventatively rather than only during illness.
Reference: Elderberry for prevention and treatment of viral respiratory illnesses[32:20] Collagen
Collagen is not a complete protein, but it provides amino acids that may support hair, skin, nails, and connective tissue. It is generally not the best option for post-exercise recovery compared to complete proteins like whey.
Reference: Collagen Protein Ingestion during Recovery from Exercise Does Not Increase Muscle Connective Protein Synthesis Rates[34:50] The Vitamin Shoppe
The Vitamin Shoppe is a leader in the space.
Reference: The Vitamin Shoppe[58:15] Beauty Standards
Beauty standards and social media can contribute to body image concerns, including body dysmorphia.
Reference: Association between beauty standards shaped by social media and body dysmorphia among Egyptian medical studentsEpisode 2 Creatine Explained + Colloidal Silver & Bioavailability
[1:03:22] BioSNEDS Berberine
The BioSNEDs version of berberine is reported to be 15 times better absorbed.
Reference: Berberine: The All-In-One Health Enhancer[1:03:21] Berberine's Absorption
Berberine has very low typical absorption, estimated at around 0.67%.
Reference: Liposomal Delivery as a Strategy to Improve Berberine Bioavailability[1:04:54] BioSNEDS' Curcumin
BioSNEDS’s curcumi had 40 times better absorption.
Reference: Curcumin: The Powerhouse for Holistic Health[1:04:53] Turmeric's First Pass
Over 90% of the turmeric is eliminated during first-pass metabolism.
Reference: Chemopreventive efficacy of oral curcumin: a prodrug hypothesis[1:09:05] Gratitude and the Immune System
The intention of being grateful in your life may help improve immune system markers.
Reference: Major Depression[1:09:05] Anxiety and Gratitude
You cannot be anxious and grateful at the same time.
Reference: Effects of gratitude intervention on mental health and well‐being among workers[2:20] Turmeric's Active Compound
The active compounds in turmeric are curcuminoids.
Reference: Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers[4:40] Creatine and Bodybuilding
Creatine first gained popularity in the bodybuilding world, but research on its effects dates back over 50 years. Early studies—some conducted in military settings—explored its impact on energy, endurance, and strength.
Reference: Beyond Muscles: The Untapped Potential of Creatine[5:15] Creatine at the Cellular Level
Creatine works at the cellular level to help regenerate energy, allowing your muscles to push past fatigue and perform better during weightlifting.
Reference: Effects of Creatine Supplementation and Resistance Training[5:30] Feeling Effects of Creatine
You can feel the effects of creatine relatively quickly—often within just a few days.
Reference: Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation[5:55] Cognitive Effects of Creatine
Recent research suggests creatine may also be an effective tool for supporting cognitive health.
Reference: The effects of creatine supplementation on cognitive function in adults[6:55] Creatine and ATP Recycling
Creatine works at the cellular level by helping recycle ATP—the body’s primary energy molecule—so it makes sense that it can also help energize neurons in the brain.
Reference: Creatine and creatinine metabolism[7:45] Creatine Loading Cycle
There’s some debate around dosing—especially the “loading phase,” which was traditionally around 20g per day for about two weeks.
Reference: Muscle creatine loading in men[9:30] Dosing for Creating
The typical daily supplemental dose of creatine is 3 to 5 grams, with the goal of reaching what’s known as muscle saturation.
Reference: International Society of Sports Nutrition position stand[10:15] 20g of Creatine is a Waste
Regardless of whether you use a loading phase or not, you’ll still reach muscle saturation. The traditional 20g loading phase is unnecessary.
Reference: Muscle creatine loading in men[10:45] Creatine - No Side Effects
No long-term side effects have been identified with creatine use.
Reference: International Society of Sports Nutrition position stand[12:00] Creatine Powder is the Most Stable Form
Creatine is most stable in its powder form. Outside of that, other forms can present stability challenges.
Reference: Analysis of the efficacy, safety, and regulatory status of novel forms of creatine[12:25] Creatine Gummies
Recent reports have found that some creatine gummies do not meet their labeled dosage claims.
Reference: Those Creatine Gummies You Bought Online Might Not Contain Any Creatine[13:30] Downside to Creatine Gummies
There have been recent reports of creatine gummies not meeting their labeled dosage claims. When creatine is improperly formulated or stored, it can potentially degrade into creatinine, reducing effectiveness and raising concerns about product quality and stability.
Reference: Analysis of the efficacy, safety, and regulatory status of novel forms of creatine[13:50] Creatine in Drink Form
Getting creatine into drinks in a stable format requires careful formulation. It’s important to look at stability studies, since creatine can degrade over time depending on factors like temperature, pH, and storage conditions.
Reference: Evaluation of the stability of creatine in solution prepared from effervescent creatine formulations[14:40] Creatine is Safe for Women
Creatine is safe for women and does not cause male characteristics such as facial hair.
Reference: International Society of Sports Nutrition position stand[14:50] Creatine is Safe and Effective
Creatine is both safe and effective.
Reference: International Society of Sports Nutrition position stand[16:25] HMB Helps You Retain Muscle
HMB helps support muscle retention. Creatine and HMB can be a worthwhile combination, especially during a weight-loss regimen such as with GLP-1 therapies, as they may help support muscle maintenance while losing fat.
Reference: Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults[19:00] EPA and DHA are Important
EPA and DHA are important for cell structure and function, and they also play a key role in supporting cognitive health.
Reference: Effects of Omega-3 Polyunsaturated Fatty Acids on Brain Functions[19:30] NAC and Glutathione
NAC converts to glutathione in the body.
Reference: Medical and Dietary Uses of N-Acetylcysteine[19:30] NAC - Wrongly Categorized
NAC (N-acetylcysteine) was often pigeonholed as a drug, despite its broader applications and use as a supplement.
Reference: N-Acetylcysteine[20:15] Alpha GPC at High Doses
Alpha GPC is sometimes used at higher doses, but some research suggests it may be best used in cycles rather than continuously—for example, limiting use to around six months at a time.
Reference: Alpha-Gpc - Uses, Side Effects, and More[21:00] Intermittent Fasting
Intermittent fasting has been linked to weight loss and improvements in energy levels for some people.
Reference: Intermittent fasting and weight loss[23:00] Curcumin and Absorption
Curcumin is not well absorbed on its own.
Reference: Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers[23:15] Vitamin D3
Vitamin D3 has often been referred to as the “vitamin of the decade”.
Reference: Vitamin D: a D-Lightful health perspective[24:55] Magnesium is Crucial
Magnesium is crucial for helping muscles relax in the body, while calcium supports muscle contraction. Imbalances in these minerals can contribute to muscle cramping.
Reference: Magnesium in Disease Prevention and Overall Health[25:20] Magnesium Dosing
100 mg of magnesium provides about 24% of the RDI. In many cases, doses above 200–300 mg may be unnecessary unless there are specific circumstances or other factors involved.
Reference: Magnesium Fact Sheet for Health Professionals[25:20] Magnesium - Bowel Tolerance
Magnesium glycinate is a well-absorbed form of magnesium. With supplementation, bowel tolerance can vary—some people gradually build up intake over time as the body adapts.
Reference: Adequacy Rate of Magnesium Citrate Bowel Preparation in a Large Retrospective Cohort[26:50] DeHydration
The majority of people are chronically dehydrated.
Reference: Inadequate Hydration, BMI, and Obesity Among US Adults[27:00] Function of Electrolytes
Electrolytes play a key role in maintaining fluid balance, nerve signaling, and muscle function. The three main electrolytes are sodium, potassium, and chloride.
Reference: Electrolytes[29:00] Sugar and Electrolytes
A small amount of sugar can help electrolytes work more effectively. Around 4–6 grams of sugar can aid absorption by supporting the transport of sodium and water in the gut, helping the body take in electrolytes more efficiently.
Reference: Glucose-stimulated sodium transport by the human intestine during experimental cholera[29:30] Silver's Support
Silver is sometimes marketed for immune support, but there is no strong clinical evidence that it is effective for that purpose. It is not considered safe for routine daily use, as chronic intake of silver can lead to a condition called argyria, where silver accumulates in the body and can permanently discolor the skin.
Reference: Silver as an Antibiotic-Independent Antimicrobial[37:25] Silver's Conductivity
Silver is the most electrically conductive metal.
Reference: Electrical resistivity and conductivity[38:40] Silver's Purity
Bio-active silver hydrosols are marketed as highly purified colloidal silver products. Five-nines purity (99.999%) is significantly higher than jewelry silver, which is typically around 92.5% pure, and products like Sovereign Silver are often described as reaching this level of purity.
Reference: The Silver Story[43:10] Argyria Misinformation
Argyria misinformation is common out there. There is PR against silver, but the claim is that pure silver at low concentrations is safe.
Reference: Silver in Drinking-water[53:30] Bioavailability
Bioavailability vs absorption — absorption is what gets into the bloodstream, while bioavailability is how much of it actually remains available in the system in an active form once it’s processed.
Reference: Bioavailability Studies Submitted in NDAs or INDs[56:15] First Pass Elimination
First-pass elimination in the liver is the primary elimination pathway. High doses are often cleared quickly.
Reference: First Pass Effect[56:50] Liposomes
Liposomes can enter the bloodstream faster than standard supplements. They help compounds reach circulation more quickly.
Reference: Bioavailability of Liposomal Vitamin C in Powder Form[57:45] BioSNEDS
BioSNEDs maximize absorption and bioavailability.
Reference: BioSNEDS™ High-Bioavailability Nutraceuticals[57:46] BioSNEDS and Creatine
BioSNEDs provide up to 22x the bioavailability of standard creatine.
Reference: Creatine Monohydrate: Supporting Optimal Performance[57:47] PK Studies
Human pharmacokinetic (PK) studies are the gold standard for measuring enhanced absorption.
Reference: Bioavailability and Bioequivalence in Drug DevelopmentEpisode 1 Protein Supplements: Whey, Collagen & Plant Protein Explained
[12:10] Protein's Role
Protein plays a vital role in the body, with muscle making up roughly 30–40% of your total composition. Its primary function is to support repair, recovery, and growth across muscles, bones, and organs.
Reference: Skeletal Muscle[12:46] Protein & Metabolism
Protein is directly involved in metabolic processes throughout the body.
Reference: What are proteins and what do they do?[12:48] Muscle & Fat Burning
The exercise of stimulating muscle growth helps you burn fat.
Reference: Non-exercise activity thermogenesis (NEAT)[13:45] Collagen (Pt 2)
The amino acids in collagen help feed that part of the body. (hair, skin, nails)
Reference: Oral Collagen Supplementation: A Systematic Review of Dermatological Applications[13:45] Collagen
Collgen for Hair Skin and Nails: Collagen entered market on anti-aging messaging. (hair, skin, nails).
Reference: Collagen peptides has beneficial effects on human skin physiology[14:30] Whey Protein - Most Popular Protein
Whey protein is the most popular protein in the market.
Reference: Whey Protein Market (2025–2033)[15:30] Protein Quality
Whey Protein concentrates originally always contained lactose but nowadays available in lactose free versions.
Reference: Advanced Dairy Chemistry: Volume 1: Proteins[16:25] Protein Evaluation
Protein Scoring systems: scoring the best proteins for the human body
Reference: Dietary Protein Quality Evaluation in Human Nutrition[17:00] Animal vs Plant Protein
Plant proteins have a low biological value score
Reference: A Review on Nutritional Quality of Animal and Plant Proteins[17:25] DIAAS
The Digestible Indispensable Amino Acid Score (DIAAS) is considered the most sophisicated proteing scoring system.
Reference: Digestible indispensable amino acid score (DIAAS): 10 years on[17:45] DIAAS and Plant Protein
Plant proteins score lower in DIAAS score.
Reference: Can the digestible indispensable amino acid score methodology decrease protein malnutrition[18:15] DIAAS and Whey Protein
Whey protein gets over 100 on DIAAS score, plant proteins typically provide a DIAAS score around 70-80, and collagen gets a zero on DIAAS score.
Reference: Values for digestible indispensable amino acid scores[19:00] Whey Protein and Muscle Repair
Whey protein has the near perfect amino acid structure that is best for helping support muscle repair and recovery.
Reference: A Brief Review of Critical Processes in Exercise-Induced Muscular Hypertrophy[21:00] Grass-Fed Whey
Grass-fed whey protein is important because its nutritional value differs from conventional options. Cows raised on grass produce higher-quality milk—where whey is derived—and are typically not treated with added hormones, resulting in a cleaner product for consumption.
Reference: A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef[25:00] Probiotics
Probiotics are important for immune health and digestion.
Reference: Probiotics and prebiotics in intestinal health and disease: from biology to the clinic[26:05] Colostrum
Colostrum contains immunoglobulins and is important for digestion and immune function.
Reference: Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease[26:35] Melatonin
Melatonin is a synthetic hormone most of the time, at least 99.99% of the market.
Reference: Study uncovers significant labeling inaccuracies in melatonin supplements[28:15] Creatine and Strength
Creatine not only helps with the strength and endurance, but current research also showing it supports cognitive health.
Reference: Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials[29:15] Creatine and HMB
HMB helps you retain muscle you worked so hard in the gym for. HMB also helps preserve muscle and in some cases help you build it back.
Reference: Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults[29:45] Medicinal Mushrooms
Medicinal mushrooms: enhance brain function and immune function.
Reference: Mushroom immunomodulators: unique molecules with unlimited applications[30:30] NMN
NMN in B-vitamin familiy sort of – came on scene due to anti-aging interest. NAD is not well absorbed or utiliezed and NMN seems to be better utilized.
Reference: Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women[31:10] Energy Drinks
Energy drinks are dangerous. Stimulants can increase blood pressure and heart rate unnaturally.
Reference: Impact of High Volume Energy Drink Consumption on Electrocardiographic and Blood Pressure Parameters: A Randomized Trial[32:30] Guayusa
Other tools for energy: Guayusa that has almost no caffeine but interesting say of increasing energy. Or Ginseng or Ashwagandha can be useful for energy.
Reference: Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis[35:50] Absorption - Curcumin
Reference: Curcumin: A Review of Its’ Effects on Human Health[35:50] Absorption - Berberine
Only 67% of Berberine is absorbed into the body.
Reference: Bioavailability Study of Berberine and the Enhancing Effects of TPGS on Intestinal Absorption in Rats[35:50] Absorption - Resveratrol
Less than 1% of Resveratrol is absorbed into the body.
Reference: High absorption but very low bioavailability of oral resveratrol in humans[35:50] Absorption
Many supplements are poorly absorbed by the body (low bioavailability), meaning only a small percentage is actually utilized.
Reference: High absorption but very low bioavailability of oral resveratrol in humans[39:40] Anxiety Trends
Research suggests anxiety levels among adults have increased 25-50% in the last 5 years.
Reference: American Adults Express Increasing Anxiousness in Annual Poll; Stress and Sleep are Key Factors Impacting Mental Health[44:42] Meditation & Deep Breathing - Disease States
Certain disease states and conditions like IBS that can be reduced.
Reference: Slow, deep breathing intervention improved symptoms and altered rectal sensitivity in patients with constipation-predominant irritable bowel syndrome[44:42] Meditation & Deep Breathing - Energy
Deep breathing can increase energy.
Reference: How Breath-Control Can Change Your Life: A Systematic Review on Psycho-Physiological Correlates of Slow Breathing[44:42] Meditation & Deep Breathing - Anxiety
Meditation and deep breathing can lower anxiety and blood pressure.
Reference: Meditation and blood pressure: a meta-analysis of randomized clinical trials